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There may be also a gap in the quantity of research exertion put into learning the various sirtuin isoforms. SIRT1 is undoubtedly the most researched isoform, with over 11,000 articles indexed in PubMed. Compared, the opposite two most researched isoforms, SIRT2 and SIRT3, with each other have only all over 3,700 articles or blog posts. This dispar